Automated medical diagnosis of alzheimer´s disease using an Efficient Net convolutional neural network

Producción CientíficaAlzheimer's disease (AD) poses an enormous challenge to modern healthcare. Since 2017, researchers have been using deep learning (DL) models for the early detection of AD using neuroimaging biomarkers. In this paper, we implement the EfficietNet-b0 convolutional neural network (CNN) with a novel approach—"fusion of end-to-end and transfer learning"—to classify different stages of AD. 245 T1W MRI scans of cognitively normal (CN) subjects, 229 scans of AD subjects, and 229 scans of subjects with stable mild cognitive impairment (sMCI) were employed. Each scan was preprocessed using a standard pipeline. The proposed models were trained and evaluated using preprocessed scans. For the sMCI vs. AD classification task we obtained 95.29% accuracy and 95.35% area under the curve (AUC) for model training and 93.10% accuracy and 93.00% AUC for model testing. For the multiclass AD vs. CN vs. sMCI classification task we obtained 85.66% accuracy and 86% AUC for model training and 87.38% accuracy and 88.00% AUC for model testing. Based on our experimental results, we conclude that CNN-based DL models can be used to analyze complicated MRI scan features in clinical settings.Publicación en abierto financiada por el Consorcio de Bibliotecas Universitarias de Castilla y León (BUCLE), con cargo al Programa Operativo 2014ES16RFOP009 FEDER 2014-2020 DE CASTILLA Y LEÓN, Actuación:20007-CL - Apoyo Consorcio BUCL

An Approach to Detect Chronic Obstructive Pulmonary Disease Using UWB Radar-Based Temporal and Spectral Features

Chronic obstructive pulmonary disease (COPD) is a severe and chronic ailment that is currently ranked as the third most common cause of mortality across the globe. COPD patients often experience debilitating symptoms such as chronic coughing, shortness of breath, and fatigue. Sadly, the disease frequently goes undiagnosed until it is too late, leaving patients without the care they desperately need. So, COPD detection at an early stage is crucial to prevent further damage to the lungs and improve quality of life. Traditional COPD detection methods often rely on physical examinations and tests such as spirometry, chest radiography, blood gas tests, and genetic tests. However, these methods may not always be accurate or accessible. One of the key vital signs for detecting COPD is the patient’s respiration rate. However, it is crucial to consider a patient’s medical and demographic characteristics simultaneously for better detection results. To address this issue, this study aims to detect COPD patients using artificial intelligence techniques. To achieve this goal, a novel framework is proposed that utilizes ultra-wideband (UWB) radar-based temporal and spectral features to build machine learning and deep learning models. This new set of temporal and spectral features is extracted from respiration data collected non-invasively from 1.5 m distance using UWB radar. Different machine learning and deep learning models are trained and tested on the collected dataset. The findings are promising, with a high accuracy score of 100% for COPD detection. This means that the proposed framework could potentially save lives by identifying COPD patients at an early stage. The k-fold cross-validation technique and performance comparison with the state-of-the-art studies are applied to validate its performance, ensuring that the results are robust and reliable. The high accuracy score achieved in the study implies that the proposed framework has the potential for the efficient detection of COPD at an early stage

Plot census of the avifauna of an aspen association.

http://deepblue.lib.umich.edu/bitstream/2027.42/52496/1/928.pdfDescription of 928.pdf : Access restricted to on-site users at the U-M Biological Station

Observations on the ontogeny of behavior in Bombycilla cedrorum.

http://deepblue.lib.umich.edu/bitstream/2027.42/52497/1/929.pdfDescription of 929.pdf : Access restricted to on-site users at the U-M Biological Station

Periodontitis como factor de riesgo en pacientes con enfermedad Aterosclerótica aguda y crónica

Diversos estudios han señalado que el desarrollo de la arterosclerosis estaría relacionado con infecciones directas de microorganismos y/o presencia de marcadores inflamatorios, entre los cuales se encuentran los de origen periodontal. El presente estudio tuvo por finalidad identificar si la periodontitis está relacionada con el síndrome coronario agudo o con la cardiopatía coronaria crónica en forma diferente. Para aclarar este tema se seleccionaron a 90 pacientes de ambos sexos, que se encontraban en el Servicio de Cardiología del Hospital Edgardo Rebagliati Martins, con los diagnósticos de Síndrome Coronario Agudo (30 pacientes), Enfermedad Coronaria Crónica (30 pacientes) y un grupo control (30 pacientes). A todos ellos se les evaluó clínicamente el estado periodontal, utilizando el índice de Ramfjord. Los resultados evidenciaron una tendencia del grupo con Enfermedad Coronario Crónica a padecer gingivitis, mientras que en el grupo con Síndrome Coronario Agudo esta tendencia se orientó hacia algún tipo de periodontitis, hallándose una relación significativa entre estas variables (p<0.05). En conclusión, la presencia de periodontitis se relaciona con el Síndrome Coronario Agudo, pero no con la Enfermedad Coronaria Crónica

Deep Learning-Based Multiclass Instance Segmentation for Dental Lesion Detection

Automated dental imaging interpretation is one of the most prolific areas of research using artificial intelligence. X-ray imaging systems have enabled dental clinicians to identify dental diseases. However, the manual process of dental disease assessment is tedious and error-prone when diagnosed by inexperienced dentists. Thus, researchers have employed different advanced computer vision techniques, as well as machine and deep learning models for dental disease diagnoses using X-ray imagery. In this regard, a lightweight Mask-RCNN model is proposed for periapical disease detection. The proposed model is constructed in two parts: a lightweight modified MobileNet-v2 backbone and region-based network (RPN) are proposed for periapical disease localization on a small dataset. To measure the effectiveness of the proposed model, the lightweight Mask-RCNN is evaluated on a custom annotated dataset comprising images of five different types of periapical lesions. The results reveal that the model can detect and localize periapical lesions with an overall accuracy of 94%, a mean average precision of 85%, and a mean insection over a union of 71.0%. The proposed model improves the detection, classification, and localization accuracy significantly using a smaller number of images compared to existing methods and outperforms state-of-the-art approaches

SARSMutOnto: An Ontology for SARS-CoV-2 Lineages and Mutations

Mutations allow viruses to continuously evolve by changing their genetic code to adapt to the hosts they infect. It is an adaptive and evolutionary mechanism that helps viruses acquire characteristics favoring their survival and propagation. The COVID-19 pandemic declared by the WHO in March 2020 is caused by the SARS-CoV-2 virus. The non-stop adaptive mutations of this virus and the emergence of several variants over time with characteristics favoring their spread constitute one of the biggest obstacles that researchers face in controlling this pandemic. Understanding the mutation mechanism allows for the adoption of anticipatory measures and the proposal of strategies to control its propagation. In this study, we focus on the mutations of this virus, and we propose the SARSMutOnto ontology to model SARS-CoV-2 mutations reported by Pango researchers. A detailed description is given for each mutation. The genes where the mutations occur and the genomic structure of this virus are also included. The sub-lineages and the recombinant sub-lineages resulting from these mutations are additionally represented while maintaining their hierarchy. We developed a Python-based tool to automatically generate this ontology from various published Pango source files. At the end of this paper, we provide some examples of SPARQL queries that can be used to exploit this ontology. SARSMutOnto might become a ‘wet bench’ machine learning tool for predicting likely future mutations based on previous mutations

Breast Cancer Prediction Using Fine Needle Aspiration Features and Upsampling with Supervised Machine Learning

Breast cancer is one of the most common invasive cancers in women and it continues to be a worldwide medical problem since the number of cases has significantly increased over the past decade. Breast cancer is the second leading cause of death from cancer in women. The early detection of breast cancer can save human life but the traditional approach for detecting breast cancer disease needs various laboratory tests involving medical experts. To reduce human error and speed up breast cancer detection, an automatic system is required that would perform the diagnosis accurately and timely. Despite the research efforts for automated systems for cancer detection, a wide gap exists between the desired and provided accuracy of current approaches. To overcome this issue, this research proposes an approach for breast cancer prediction by selecting the best fine needle aspiration features. To enhance the prediction accuracy, several feature selection techniques are applied to analyze their efficacy, such as principal component analysis, singular vector decomposition, and chi-square (Chi2). Extensive experiments are performed with different features and different set sizes of features to investigate the optimal feature set. Additionally, the influence of imbalanced and balanced data using the SMOTE approach is investigated. Six classifiers including random forest, support vector machine, gradient boosting machine, logistic regression, multilayer perceptron, and K-nearest neighbors (KNN) are tuned to achieve increased classification accuracy. Results indicate that KNN outperforms all other classifiers on the used dataset with 20 features using SVD and with the 15 most important features using a PCA with a 100% accuracy score